Informations

Type
inproceedings
Key
2016_icra_mellal
Authors
Mellal, Lyès and Folio, David and Karim Belharet and Ferreira, Antoine
http://doi.org/10.1109/ICRA.2016.7487338
HAL
01342018
2016_icra_mellal.
Metrics

Abstract

This paper presents an optimal design strategy for magnetic targeting of therapeutic drugs. In this study, to maximize the effect of the treatment and minimize adverse effects on the patient, mathematical models have been developed to find the number and the size of the boluses with respect to the growth of a tumor. Using these models, control strategies are developed to establish a schedule that allows the physician to administer the medication while respecting borne by the patient doses. To transport the drugs, we use therapeutic magnetic boluses composed of magnetic particles aggregates as navigable agents controlled by magnetic gradients. Based on the optimal design of the bolus, an experimental investigation is carried out in millimeter-sized fluidic artery vessels to demonstrate the steerability of the magnetic bolus under different velocity, shear-stress and trajectory constraints with a laminar viscous fluidic environment.

Keywords


BibTeX:

 @inproceedings{2016_icra_mellal,
  title = {Optimal Control of Multiple Magnetic Microbeads Navigating in Microfluidic Channels},
  author = {Mellal, Lyès and Folio, David and {Karim Belharet} and Ferreira, Antoine},
  booktitle = {IEEE International Conference on Robotics and Automation (ICRA\'2016)},
  year = {2016},
  doi = {10.1109/ICRA.2016.7487338},
  month = may,
  pages = {1921--1926},
  publisher = {IEEE},
  address = {Stockholm, Sweden},
  hal = {01342018},
  keywords = {controllability,drug delivery systems,flow control,laminar flow,linear quadratic control,microchannel flow,observability,optimal control,LQI,controllability conditions,drug targeting applications,laminar viscous fluidic environment,linear quadratic with integral action control,magnetic gradient fields,microfluidic channels,millimeter-sized fluidic artery vessels,multiple magnetic microbeads,observability conditions,optimal control,therapeutic magnetic microbeads,trajectory constraints,velocity constraints,Controllability,Magnetic moments,Magnetic resonance imaging,Magnetic separation,Magnetic tunneling,Micromagnetics,Saturation magnetization}
}